Harītakī (Terminalia chebula) as an Immunomodulator: Evidence from Āyurveda and Contemporary Biomedical Research
DOI:
https://doi.org/10.63247/3048-7390.vol.2.issue3.4Keywords:
Rasyana, Immunomodulator, Haritaki , Vyadhiksamtwa,, Terminelia ChebulaAbstract
This paper explores the immunomodulatory potential of Terminalia chebula (Haritaki), a revered herb in Ayurveda known for its multifaceted health benefits. Haritaki is categorized as a Rasayana in Ayurvedic texts, signifying its rejuvenating properties. The research synthesizes findings from various studies to elucidate Haritaki's impact on the immune system through its diverse pharmacological actions. It examines Haritaki's ability to enhance both cellular and humoral immunity, supported by evidence of increased lymphocyte proliferation, elevated antioxidant enzyme levels, and modulation of cytokine production. Furthermore, the study investigates Haritaki's therapeutic efficacy against specific diseases and its potential as an adjunct therapy in conditions like diabetes and amoebiasis. Nowadays different modern researches have reveal edits chemical components and pharmacological activities. Main phytochemicals of haritaki are chebulic acid, gallic acid, chebulagic acid, titerpenoids and anthraquinones.[1] The findings underscore Haritaki's significance as an immunostimulant and its potential applications in promoting overall health and combating immune-related disorders.
Methods: All the Ayurveda literature, i.e., Charak Samhita, Sushrut Samhita, Bhavaprakasha Nighantu, and all articles related to haritaki is analysed and data collected related to haritaki to assess the role of Immunomodulator.
Result: A review of classical Ayurvedic literature and modern research evidence suggests that Haritaki holds significant promise effect as immunomodulator, owing to its ability to balance all three doshas, enhance Ojas and Agni & offer scientifically supported antioxidant activity.
Discussion: Haritaki is considered a Rasayana Herb for supporting longevity and improving resistance to illness. Haritaki is a foundational herb in Ayurveda, earning titles like the “king of medicine” due to its wide-ranging therapeutic benefits.[2]
References
1) Sharma S, Singh B, Kumar H. A critical review of pharmacological actions of Harītakī (Terminalia chebula Retz.) in classical texts. J Ayurveda Integr Med Sci. 2019;4(4):258–269.
2) Bag P, Bhattacharyya S, Chattopadhyay S. The development of Terminalia chebula Retz. (Combretaceae) in clinical research. Asian Pac J Trop Biomed. 2013;3(3):244–252.
3) Quotery. Health is the soul that animates all the enjoyments of life [Internet]. 2024 [cited 2024 May 22]. Available from: https://www.quotery.com/quotes/health-soul-animates-enjoyments-life
4) Wikipedia contributors. Rasāyana [Internet]. San Francisco: Wikimedia Foundation; 2024 May 1 [cited 2025 Nov 22]. Available from: https://en.wikipedia.org/wiki/Rasayana
5) Agniveśa. Carakasaṃhitā. Cikitsāsthāna, Rasāyanā (Abhyāmalakī-rasāyanāpāda); 1/1/7–8 [Internet]. Ayurveda360; cited 2025 Nov 30. Available from: https://ayurveda360.in/ebooks-esamhita-ecaraka-cikitsasthana-rasayana-adhyaya/
6) Goyal M. Rasāyana in perspective of the present scenario. Ayu. 2018;39(2):63–64. doi:10.4103/ayu.AYU_300_18
7) Bhāvamiśra. Bhāvaprakāśa Nighaṇṭu. Harītakyādivarga; 2/18–24 [Internet]. Ayurveda360; cited 2025 Nov 30. Available from: https://ayurveda360.in/ebooks-enighantu-bhavaprakasha-nighantu-hareetakyadivarga/
8) Sharma M, Sahu S. Gallery of Medicinal Plants (Dravyaguṇa). New Delhi: Thieme Medical and Scientific Publishers Pvt Ltd; 2020.
9) Nagarathna PKM, Reena K, Sriram R, Wesley J. Review on immunomodulation and immunomodulatory activity of some herbal plants. Int J Pharm Sci Rev Res. 2013;22(1):223–230.
10) Tripathi JS, Singh RH. The concept and practice of immunomodulation in Ayurveda and the role of Rasāyanas as immunomodulators. Anc Sci Life. 1999;19(1–2):1–5.
11) Patil US, Jaydeokar AV, Bandawane DD. Immunomodulators: a pharmacological review. Int J Pharm Pharm Sci. 2012;4(Suppl 1):6–10.
12) Institute for Quality and Efficiency in Health Care (IQWiG). The innate and adaptive immune systems [Internet]. Cologne; 2023 Aug 14 [cited 2025 Jul 17]. Available from: https://www.iqwig.de
13) Strzelec M, Detka J, Mieszczak P, Sobocińska MK, Majka M. Immunomodulation—current state-of-the-art and new therapeutic strategies. Front Immunol. 2023;14:1127704. doi:10.3389/fimmu.2023.1127704
14) Bulbul MRH, Chowdhury MNU, Naima TA, Sami SA, Imtiaj MS, Huda N, et al. A comprehensive review on the pharmacological perspectives of Terminalia chebula Retz. Heliyon. 2022;8(8):e10220. doi:10.1016/j.heliyon.2022.e10220
15) Mane NV, Topre SG, Firdaus S. Immunomodulatory effects of Harītakī (Terminalia chebula Retz.). World J Pharm Res. 2020;9(7):1–10.
16) Afshari AR, Sadeghnia HR, Mollazadeh H. Potential mechanisms of Terminalia chebula in Alzheimer’s disease. Adv Pharmacol Sci. 2016;2016:8964849. doi:10.1155/2016/8964849
17) Saha S, Verma RJ. Antioxidant activity of polyphenolic extract of Terminalia chebula fruits. J Taibah Univ Sci. 2015;10(6):805–812. doi:10.1016/j.jtusci.2014.09.003
18) Saleem A, Husheem M, Härkönen P, Pihlaja K. Inhibition of cancer cell growth by phenolics of Terminalia chebula. J Ethnopharmacol. 2002;81(3):327–336. doi:10.1016/S0378-8741(02)00099-5
19) Gandhi NM, Nair CK. Radiation protection by Terminalia chebula. Mol Cell Biochem. 2005;277(1–2):43–48. doi:10.1007/s11010-005-4819-9
20) Suguna L, Singh S, Sivakumar P, Sampath P, Chandrakasan G. Influence of Terminalia chebula on wound healing. Phytother Res. 2002;16(3):227–231. doi:10.1002/ptr.827
21) Seo JB, Jeong JY, Park JY, Jun EM, Lee SI, Choe SS, et al. Anti-arthritic and analgesic effects of Terminalia chebula extract. Biomol Ther (Seoul). 2012;20(1):104–112. doi:10.4062/biomolther.2012.20.1.104
22) Sharma P, Prakash T, Kotresha D, Ansari MA, Kumar B, et al. Antiulcerogenic activity of Terminalia chebula. Pharm Biol. 2011;49(3):262–268. doi:10.3109/13880209.2010.503709
23) Sultan MT, Anwar MJ, Imran M, Khalil I, Saeed F, et al. Phytochemical profile and health properties of Terminalia chebula. Int J Food Prop. 2023;26(1):526–551. doi:10.1080/10942912.2023.2166951
24) Mazloom BF, Edalatmanesh MA. Effect of gallic acid on pituitary–ovary axis in PCOS rats. Rep Health Care. 2017;3(1):41–47.
25) Lee HS, Koo YC. Preventive effects of chebulic acid on endothelial dysfunction. J Ethnopharmacol. 2010;131(3):567–574. doi:10.1016/j.jep.2010.07.039
26) Huang YN, Zhao DD, Gao B. Anti-hyperglycemic effect of chebulagic acid. Int J Mol Sci. 2012;13(5):6320–6333. doi:10.3390/ijms13056320
27) Manzoor F, Un Nisa M, Hussain HA, Anwar H, Ahmad N, et al. Hydrolysable tannins in reproductive health. Food Sci Technol. 2021;42:e63720. doi:10.1590/FST.63720
28) Shivaprasad HN, Kharya MD, Rana AC, Mohan S. Immunomodulatory activity of Terminalia chebula. Pharm Biol. 2006;44(1):32–34. doi:10.1080/13880200500530542
29) Na Takuathung M, Wongnoppavich A, Jaijoy K, Soonthornchareonnon N, Sireeratawong S. Antioxidant and antitumorigenic activities of Terminalia chebu..la. Nat Prod Commun. 2023;18(6):1–12. doi:10.1177/1934578X231176925
30) Aher V, Wahi AK. Immunomodulatory activity of Terminalia chebula. Trop J Pharm Res. 2011;10(5):593–598. doi:10.4314/tjpr.v10i5.5
31) Khan KH. Immunomodulatory activity of Terminalia chebula against Salmonella typhimurium. Rec Res Sci Tech. 2009;1(1):211–216.
32) Sohni YR, Kaimal P, Bhatt RM. Antiamoebic effect of herbal extracts. J Ethnopharmacol. 1995;45(1):43–52. doi:10.1016/0378-8741(94)01194-5
33) Mukherjee PK, Nema NK, Bhadra S, Mukherjee D, Braga FC, Matsabisa MG. Immunomodulatory leads from medicinal plants. Indian J Tradit Knowl. 2014;13(2):235–256.
34) Dwivedi S, Dwivedi A, Kapadia R, Kaul S. Anthelmintic activity of Terminalia chebula. Ethnobot Leaflets. 2008;12:741–743.
35) Aher VD. Immunomodulatory effect of Terminalia chebula fruits. J Pharm Sci Res. 2010;2(9):539–544.
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Copyright (c) 2025 Dr. Tanuja Sagar, Prof. (Dr.) Unnikrishnan S., Dr. Rohit Mandal (Author)
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