Svarṇaprāśana: Mechanistic Perspectives from Traditional Ayurveda to Modern Nanomedicine
DOI:
https://doi.org/10.63247/3048-7390.vol.2.issue2.7Keywords:
Svarṇaprāśana, Immunity, Nanomedicine, ĀyurvedaAbstract
Introduction: Svarṇaprāśana, the administration of processed gold (Svarṇa Bhasma) with Ghṛta (clarified butter) and Madhu (honey) as a Lehaṇa (lickable electuary), is a classical pediatric intervention described in Kāśyapa Saṁhitā. Traditionally indicated to enhance intellect, digestion, strength, and longevity, it has recently gained scientific attention for potential immunomodulatory, nootropic, and anti-infective effects.
Methods: This review synthesizes classical Āyurvedic literature, pharmaceutics, and contemporary experimental and clinical studies to explore the mode of action of Svarṇaprāśana. Emphasis was placed on physicochemical transformation of gold, bioavailability enhancement through lipid-sugar vehicles, and immunological mechanisms.
Results: Evidence suggests that Amṛtīkaraṇa and allied Saṁskāras transform Svarṇa into biologically active nano- or microparticulate forms. The Ghṛta–Madhu vehicle enhances uptake and creates an amphipathic, liposomal-like delivery system. Preclinical and clinical data indicate immune benefits including macrophage activation, enhanced antigen presentation, and cytokine modulation, alongside potential cognitive and anti-infective effects.
Discussion: Svarṇaprāśana represents a classical Āyurvedic intervention with translational relevance to modern nanomedicine. Standardization, safety, and rigorous clinical studies remain priorities to validate and optimize its therapeutic potential.
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Copyright (c) 2025 Dr. Mangesh Suresh Khillari, Dr. Avinash Vitthalrao Kaware, Dr. Dinar Shivaraj Sawant, Dr. Bhaskar Subhash Jadhav, Dr. Gaurav Manohar Deore, Dr. Divya Patil (Author)
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